关桂君课题组在青鳉Gsdf/TGFβ旌旗灯号调控生殖细胞增殖的份子机制研讨中取得停顿

发布日期: 2021-12-23 责任编辑: 蔡霞本条信息已被检查了 207设置

qingjiangxingxiantixibaoyanshengyinzi(gsdf)shitgfβjiashuchengyuanzhiyi,yibeizhengmingshiqidongshengzhixibaoxiongxingfenjiedeguanjiankaiguanzhiyi。

weishenqielinghuigsdfdiaokongshengzhixibaojinruxiongxingfenjiedefenzijingqidenghaotonglu,guanguijunketizuyongkangzuansuanbiaoqiankangti“xiala”qingjiangchengshujingchaotiquwu,caozonglc-ms/mszhipuchanfa,qudebaojiangnengyuanluanbaiqinglian2、zhenheduotaidanwuyinzi1α(eef1α)hejidongluanbaisidengqianfudegsdflianxiluanbaiyinziqun。jingyoujinchengjiaomushuangzajiao,duichengshudejingchaocdnawenkutingzhigsdflianxiluanbaifenzitiaoxuan,kaozhenglegsdf-dyneinyugsdf-eef1αzhijianjianjiedebiciganhua。chucifamingleduiwujizhuizhiwuguoyingjingyuanxibaogeliexiangdangzhuyaodetgfβ-dyneinfuheti,zaijizhuizhiwuqingjiangdeshengjingjinchengzhongjubeizhuyaodetuihuajijinxing。tongshijingyoujinchengmianyigongjidianzhengminggsdfheeef1αhuzuofuhetizhizaijingchaozhongbeijiancedao。gaotongliangluanbaizhizuxuechanfahetoushedianjingchaoweibujudechakanchanfaxianxian,gsdfheeef1αhuzuofuhetidequeshi,buzhizhishigsdfjingqidenghaoxialiudesmadjingqidenghaobunenglinsuanhuohua,zuduanleheneijingqidenghaozhuandao,haijihuoleeef1αjiedaodeyizucixingluanbaizhifenjiehehetangtidefenjie,zhishixyshengzhixibaodejubuxiongxingxibaohehecixingxibaozhidexingzhuangzaluan。

yantaogongxiaobiaomingqingjianggsdf(tgfβ)heeef1αfuhewujingyoujinchengdiaokongeef1αjiedaodemrnazhuanlu、xibaohejixibaozhizhijiandezhuanyun,hernafanyidenggongxiaobiangeng,diaokongshengzhixibaozengzhihepinmufenjie。zheiyixinfaming,weigsdf(tgfβ)heeef1αzaidiaokongshengzhixibao,hexiangganliandeaizhengxibaozengzhizhongdeganhuajizhiyantao,gongjileyigexindeshijiao。

shengzhixibaozhonggsdffuhewudiaokongxialuanbaizhifanyidexibaojizhibiaoshitu

该功效“A potential role for the Gsdf-eEF1α complex in inhibiting germ cell proliferation: A protein-interaction analysis in medaka (Oryzias latipes) from a proteomics”克日在Molecular & Cellular Proteomics杂志在线颁发(doi: 10.1074/mcp.RA120.002306)。关桂君课题组研讨生张新亭、常宇阳和陈良标课题组翟万营博士为本文配合第一作者,关桂君传授和陈良标传授为配合通信作者。该研讨取得了上海市水产一流学科、国度天然科学基金和科技部重点研发打算名目的帮助。

(供稿: 水产与性命学院)
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